Lions vs Cardinals Picks, Predictions, and Best Bets: 'Maserati Marv' Takes Victory Lap

The Arizona Cardinals and Detroit Lions are each looking for their second wins of 2024 when they face off at State Farm Stadium. 

Arizona piled up 41 points on the Rams last week, and the offensive onslaught was spearheaded by the breakout performance of Marvin Harrison Jr.

Find out why my Lions vs. Cardinals predictions and NFL picks expect an encore performance on Sunday, September 22.

Lions vs Cardinals prediction

My best betMarvin Harrison Jr. Over 63.5 receiving yards (-115 at BetMGM)

My analysis

After recording just one catch for four yards on three targets in his Week 1 debut, Marvin Harrison Jr. broke out in a big way last week. He led the Arizona Cardinals with eight targets, catching four of them for 130 yards and two touchdowns. 

The rookie wide receiver showed off his explosive play ability while bringing in two touchdowns on the Cardinals’ first two drives against the Rams. The first score was a 23-yard catch before Kyler Murray and Harrison connected on a 60-yard touchdown to go up 14-0.

Arizona spread the ball around a bit more after that and fell into a run-heavy attack given the large lead, but Harrison made a statement. Murray once again has a top wide receiver who can make big plays, and the Cards rookie is going to show that off any chance he gets.

Meanwhile, the Detroit Lions have already been victimized twice by top wide receivers this season. Rams wideout Cooper Kupp hauled in 14 passes for 110 yards in Week 1, and then Bucs’ WR Chris Godwin recorded 117 yards last Sunday.

Harrison isn’t nearly as established as Kupp or Godwin, but he’s shown that he can reach this Over 63.5 yards number on just a play or two. Look for him to continue to grow his connection with Murray against the Rams.

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Lions vs Cardinals same-game parlay

Marvin Harrison Jr. Over 62.5 receiving yardsMarvin Harrison Jr. anytime touchdownCardinals +3

+375 at BetMGM

The market isn’t respecting Harrison nearly enough. Sure, it was only one game, but the Ohio State star has the pedigree and matchup to blow past this 62.5-yard mark with at least one score against the Lions.

If Harrison does that, the Cardinals should remain in the game against a Detroit team that has yet to put away anyone this season.

Learn how to bet a same-game parlay with these helpful tips and strategies.

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Lions vs Cardinals odds

Lions vs Cardinals live odds

Lions vs Cardinals opening odds

  • Spread: Detroit -3.5 | Arizona +3.5
  • Moneyline: Detroit -190 | Arizona +155
  • Over/Under: Over 51.5 | Under 51.5

Odds courtesy of BetMGM

Lions vs Cardinals spread and Over/Under analysis

  • This line hasn’t moved too much since opening at -3.5. It’s been bet down to -3 at BetMGM, with Cardinals +3 slightly juiced to -115.
  • The total also hasn’t moved much. It was briefly bet up to a flat 52.0, but is back down to 51.5 as of Saturday afternoon.

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